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Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
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Des-octanoyl-Ghrelin (rat) is a desacylated peptide derivative lacking the octanoyl modification present in ghrelin resulting in decreased affinity for the growth hormone secretagogue receptor type 1a (GHS-R1a) It modulates metabolic processes such as energy homeostasis glucose regulation insulin sensitivity and lipid metabolism primarily through alternative receptor-mediated pathways Des-octanoyl-Ghrelin (rat) exerts its biological activity via modulation of endocrine regulation and inflammatory responses Based on these pharmacological properties Des-octanoyl-Ghrelin (rat) holds research potential in studies of appetite control metabolic disorders and elucidating signaling pathways linked to metabolism-related diseases
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3-(2-chloroacetyl)-1H-indole-5-carbonitrile is a drug intermediate used as a building block in medicinal chemistry for synthesis of biologically active small molecules.
Used as a drug intermediate for the synthesis of active compounds.
Solid at room temperature, suitable for handling as a synthetic reagent.
Molecular formula: C11H7ClN2O and molecular weight 218.64 g/mol.
Provided in laboratory-scale pack sizes for research and development.
Refer to the certificate of analysis for recommended storage and handling details.
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N-(Chloroacetyl)-2-methoxybenzamide is a drug intermediate used for the synthesis of various active compounds. It is intended for research use only and is not sold to patients.
Drug intermediate
Intended for research use only
Not sold to patients
Solid appearance
Shipped at room temperature in continental US (may vary elsewhere)
Storage as powder: -20°C for 3 years, 4°C for 2 years
Storage in solvent: -80°C for 6 months, -20°C for 1 month
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Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development
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